SenzaGen attends the Biocompatibility Summit in Barcelona

SenzaGen is attending the Biocompatibility Summit in Barcelona this week, on November 27-29. The summit will address updates and changes to the ISO 10993 standards and Biocompatibility for devices with a focus on Risk Mitigation, Chemical Characterisation and Practical Implementation.

Come meet our colleagues and specialists Rose Marie Jenvert, Medical Device Project Manager and Joshua Schmidt, Business Development Director – Americas there!

To book a meeting, please email them at:

rose-marie.jenvert (a) senzagen.com
joshua.schmidt (a) senzagen.com

https://lifesciences.knect365.com/biocompatibility/

SenzaGen attends the SFT annual meeting, November 27-28

SenzaGen is attending the SFT conference (Société Française de Toxicologie) in Lille, France, on November 27-28. The conference is the French Society of Toxicology’s annual meeting and SenzaGen is present with a poster: GARD® – Genomic Allergen Rapid Detection, In vitro Safety Assessment of Skin and Respiratory Sensitizers using a Genomics Based Platform. Our French distribution partner Eurosafe is also present with a booth where you can get more information about GARD® and about our collaboration with Eurosafe.

View Live: SenzaGen’s CEO at Financial Meetings Øresund

Live presentations at Financial Meetings Øresund’s event “Sverige fortsatt starkt för Life Science?”

SenzaGen’s CEO Anki Malmborg Hager will share the inspiring story of SenzaGen and how SenzaGen’s platform GARD®, a group of tests for animal-free safety testing, can replace animal tests using genomics in test tubes to assess whether chemicals are allergenic or not.

Watch live presentation here:

http://www.financialmeetings.se/live/

SenzaGen’s CEO to speak at Financial Meetings Øresund, in Lund November 19, 2018

SenzaGen’s CEO Anki Malmborg Hager will speak at Financial Meetings Øresund, November 19, 2018.

As a speakers in the event “Sverige fortsatt starkt för Life Science? Anki will share the inspiring story of SenzaGen and how SenzaGen’s platform GARD®, a group of tests for animal-free safety testing, can replace animal tests using genomics in test tubes to assess whether chemicals are allergenic or not.

For more information and registration,
see: http://www.financialmeetings.se/arrangemang

SenzaGen hosts open webinars on Respiratory Sensitization on 4 and 5 December

In vitro testing for Respiratory Sensitizers using a genomic biomarker signature and the GARD™ technology platform

The presentations on 4 and 5 December 2018, will give insight into the latest in vitro technology for identifying respiratory sensitizers using human dendritic-like cell lines and genomics.  A thorough explanation of the GARD™ platform will be covered as well as its versatility and reliability for safety assessment applicable to all industries. Sensitization testing with GARD™ is based on functional genomics.

The presentation will cover:

  • Development of the genomic-based GARD™ test platform for skin sensitization hazard, potency classification, and now also respiratory sensitization.
  • Dendritic cells – why they are also relevant for respiratory sensitization.
  • Gene mapping – what genes are in the assay, and how are they relevant for sensitization.
  • How GARD™ can discriminate between skin and respiratory sensitization and why this is relevant.
  • Update on the development of the SenzaGen R&D pipeline including GARD™ for materials – testing medical devices, GARD™ for proteins – classification of protein sensitizers, GARD™ for mixtures – assessment of complex formulations and Unknown or Variable Composition UVCBs.

Next generation in vitro skin and respiratory sensitization testing using genomics with GARD™

The GARD™ platform is a versatile in vitro testing strategy which currently consist of three assays targeting two toxicological endpoints: skin sensitization (GARDskin & GARDpotency) and respiratory sensitization (GARDair). These assays make use of unique genomic biomarker signatures comprising genes involved in pathways known to be immunologically relevant to the sensitization process. Supported by modern technologies for pattern recognition, the large informational content provided by this approach enable for mechanism-of-action based decisions, which becomes evident in a consistently high predictive accuracy

Don’t miss the opportunity to learn more from our researchers.

Register by clicking on any of the links below.

 

European Registration
Tue 4 Dec 2018, 15:00 CET

Americas Registration
Wed 5 Dec 2018, 13:00 EST

 

SenzaGen’s presentation at Unicorn Summit

On October 10, SenzaGen participated in the Vator Securities Unicorn Summit, a capital market day organized to bring together some of the most innovative and fast-growing Swedish life science companies with investors.
Anki Malmborg Hager presented Senzagen’s developments and accelerated efforts towards further strengthening the commercial organization and the global presence of GARD®, a group of tests for animal-free safety testing. You will find Anki’s full presentation here

SenzaGen presenterar vid Vator Securities Unicorn Summit 10 oktober 2018 from Vator Securities on Vimeo.

Anki Malmborg Hager interviewed by EFN (in Swedish)

On October 15, SenzaGen’s CEO Anki Malmborg Hager was interviewed by Swedish financial media EFN about SenzaGen’s cruelty-free test platform GARD®, our business model and new sales targets. The result was a short and to-the-point interview about our core business and our future. You will find the filmed interview (in Swedish) here:

GARD™air – A novel assay for assessment of chemical respiratory sensitizers based on a genomic platform

Henrik Johansson, Andy Forreryd, Robin Gradin, Angelica Johansson, Olivia Larne, Emil Aaltonen, Anders Jerre, Carl A.K. Borrebaeck and Malin Lindstedt
SenzaGen AB, Lund, Sweden. Department of Immunotechnology, Lund, Sweden.

Introduction
Exposure to chemicals may induce allergic hypersensitivity reactions in skin or respiratory tract. To minimize exposure, chemicals are routinely screened for their sensitizing potential. Proactive identification has historically been performed using animal models, but the use of animals for safety assessment of cosmetics was recently banned within EU. Today, similar trends are spreading both globally and across industry and market segments. Methods for specific identification of respiratory sensitizers are greatly underdeveloped, with no validated, or even widely used assay readily available. Thus, there is an urgent need for development of non-animal-based methods for hazard classification of respiratory sensitizing chemicals.

GARD– Genomic Allergen Rapid Detection – is a state of the art technology platform for assessment of chemical sensitizers (Figure 1). It is based on a dendritic cell (DC)-like cell line, thus mimicking the cell type involved in the initiation of the response leading to sensitization. Following test chemical exposure, induced transcriptional changes are measured to study the activation state of the cells. These changes are associated with the immunological decision-making role of DCs in vivo and constitutes of e.g. up-regulation of co-stimulatory molecules, induction of cellular and oxidative stress pathways and an altered phenotype associated with recognition of xenobiotic matter. By using state-of-the-art gene expression technologies, high informational content data is generated, that allows the user to get a holistic view of the cellular response induced by the test substance.

Conclusion
GARDair is a novel assay for assessment of respiratory sensitizers. It is an adaptation of the GARD platform, utilizing gene expression analysis of predictive biomarker signatures and state-of-the-art data analysis methodology. GARDair has been proven functional and is currently progressing towards industrial implementation and  regulatory acceptance with financial support from the EU programme Horizon 2020. This progress includes scientific verification of results, assay optimization, assay
transfer and formal validation by a blinded ring trial.

Link to poster

A mechanistic reinterpretation of the AOP for skin sensitisation

David W Roberts, Liverpool John Moores University, Liverpool

Introduction – Non-Animal Prediction: the 21st Century Consensus
Because of the biological complexity of the skin sensitisation process no single in chemico or in vitro assay will be an appropriate replacement for an animal-based assay such as LLNA or GPMT…
…to ensure a mechanistic basis and cover the complexity, multiple methods should be integrated into a testing strategy, in accordance with the adverse outcome pathway that describes all key events in skin sensitisation.

We need an ITS based on the KEs of the AOP…but
Is that what we really need?

Conclusion

A single assay, GARD™, predicts sensitisation potential and absence of sensitisation potential better than any of, or combinations of, the OECD guideline assays DPRA, KeratinosensTM (ARE-Nrf2 ) and h-CLAT.

We do not really need an ITS covering all KE’s of the AOP.

Link to poster

blue senzagen logo

SenzaGen stärker organisationen i USA med målsättningen att öka den kommersiella närvaron genom att öka antalet licenstagare

SenzaGen fokuserar på kemikalie-, kosmetika-, läkemedels- och medicintekniska marknaderna för sin globala kommersialisering av in vitro-plattformen GARD®.

Under 2017 och 2018 har SenzaGen successivt stärkt sin kommersiella organisation och globala närvaro med nya avtal med strategiska partners. Bakgrunden till nyrekryteringen i USA är att SenzaGen avser att accelerera samarbetena både med amerikanska licenstagare och med industriella partners för utveckling av GARD®-portföljen.

“USA är en prioriterad marknad och genom rekryteringen av Joshua J. Schmidt förstärker vi vår organisation med ett betydande nätverk, kunskap och insikter om den amerikanska marknaden vilket medverkar till att vi når vår finansiella målsättning”, säger Anki Malmborg Hager, VD på SenzaGen

Joshua J. Schmidt har omfattande affärs- och vetenskaplig erfarenhet från 3M, Medtronic and Bruker Daltonics, senast som Senior Account Executive för en amerikanska CRO, Pace Analytical Life Sciences, där han arbetat med testning av farmaceutiska och medicinsktekniska produkter i USA.

“SenzaGens teknologi imponerar och har verkligen potential att väsentligt påverka kemikalie- och life science-industrin på ett positivt sätt. Jag är entusiastisk över att komma in i SenzaGen i detta skede eftersom jag ser stora möjligheter och potential för tillväxt, såväl i USA som globalt för GARD®”, säger Joshua J. Schmidt, Business Development Director på SenzaGen Inc.

I samband med att Joshua J. Schmidt utses till Business Development Director blir SenzaGen Inc ett helägt dotterbolag till SenzaGen AB (publ).

För mer information, kontakta:

Anki Malmborg Hager, VD, SenzaGen AB

Email: anki.malmborg.hager@senzagen.com

Telefon: 0768-284822

Om GARD®

GARD® är en grupp med tester för analys av kemikaliers förmåga att starta en allergisk reaktion hos människa. Genom att analysera hundratals markörer genererar GARD™ stora mängder data och levererar resultat med över 90 procents precision. Detta kan jämföras med dagens standardmetod – tester på möss – som endast uppnår 70-75 procents precision. SenzaGens test kan dessutom kvantifiera den allergiframkallande potentialen för en kemisk substans.

Om SenzaGen

SenzaGen gör det möjligt att ersätta djurförsök med genetiska tester i provrör för att bedöma om de kemikalier vi kommer i kontakt med i vår vardag är allergiframkallande. Det kan till exempel handla om kosmetika, läkemedel, livsmedel och färgämnen. Bolagets patentskyddade tester är de mest tillförlitliga på marknaden och ger mer information än traditionella utvärderingsmetoder. Testerna säljs i egen regi i Sverige och USA, och genom partners i flera andra länder. De närmaste åren kommer bolaget expandera geografiskt, knyta till sig fler distributionspartners och lansera nya, unika tester. SenzaGen har sitt huvudkontor i Lund och dotterbolag i Delaware, USA. För mer information, besök http://www.senzagen.com.

Denna information är sådan information som SenzaGen är skyldigt att offentliggöra enligt EU:s marknadsmissbruksförordning och lagen om värdepappersmarknaden. Informationen lämnades, genom ovanstående kontaktpersons försorg, för offentliggörande 11 oktober 2018 kl. 08:30.

SenzaGen är listat på Nasdaq Stockholm First North (ticker: SENZA). FNCA är bolagets Certified Adviser. Mer information om SenzaGen finns att tillgå via http://www.senzagen.com.

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