In the context of skin sensitization testing, certain groups of chemicals are considered “difficult-to-test” using conventional cell-based methods. Examples of commonly recognised “difficult-to-test” samples include:
GARDskin demonstrated over 80% predictive accuracy* for various types of difficult-to-test samples when compared to existing human data.
Supporting metabolic activation
GARDskin utilizes a dendritic-like cell line, expressing several metabolizing enzymes required for activation of pre/-pro haptens (e.g. ALDH, CYP, NAT-1).
A broad selection of solvents
The solubility for hydrophobic substances is further increased using an extended panel of non-polar solvents compatible with the test system.
GARDskin is highly sensitive, able to detect a minimum amount of substances dissolved in the cell medium.
“Applicability of GARDskin for accurate assessment of challenging substances in the context of skin sensitization testing”
*Poster abstract accepted at SOT 2020