E. Schmidt, V. Zuckerstätter, H. Gehrke | Eurofins BioPharma Product Testing Munich GmbH Introduction A skin sensitiser refers to a substance that will lead to an allergic response following skin contact as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). The potential to induce skin sensitisation is […]
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This pilot study demonstrated the applicability of the GARDTMskin assay for identification of skin sensitizers in hair dye ingredients, delivering high prediction performance, consistent with existing human data. The study also indicated that GARDTMskin is a promising in vitro model to identify skin sensitizers in natural mixtures. Link to Application Note.
Rose-Marie Jenvert, Angelica Johansson, Olivia Larne, Emelie Danefur, Emil Altonen, Anders Jerre, Robin Gradin, Gunilla Grundström. SenzaGen, Lund, Sweden. Introduction All medical devices need to be evaluated for the end point skin sensitization according to the Biological Evaluation of Medical Devices (ISO 10993-1:2018), today commonly involving in vivo assays. Here, we show that the in […]
Olivia Larne, Ulrika I Torstensdotter Mattson, Rikard Alm, and Gunilla Grundström. SenzaGen, Lund, Sweden. Introduction The GARD®skin assay is an in vitro assay developed for the assessment of skin sensitizers. It is based on SenzaCells™, a human dendritic-like cell line, and a biomarker signature analyzed by a prediction model including pattern recognition and machine learning. […]
We are excited to announce that another CRO has been fully trained on SenzaGen’s GARD technology platform and is offering GARDskin and GARDair services. As a leading provider of in vitro toxicity testing to the US and worldwide, MB Research Labs is deeply committed to their customers and is dedicated to offering the latest […]
Toxicological Sciences, kfz108, https://doi.org/10.1093/toxsci/kfz108 Henrik Johansson, Robin Gradin, Angelica Johansson, Els Adriaens, Amber Edwards, Veronika Zuckerstätter, Anders Jerre, Florence Burleson, Helge Gehrke, Erwin Roggen Abstract Proactive identification of chemicals with skin sensitizing properties is a key toxicological endpoint within chemical safety assessment, as required by legislation for registration of chemicals. In order to meet demands of increased animal welfare and facilitate increased testing efficiency […]
One of Sweden’s most famous influencers, Margaux Dietz, has visited SenzaGen in Lund. With support from the EU, SenzaGen has developed the world’s first animal-free test for respiratory allergies making our daily products safer. Margaux put a lab coat on and got to allergy test her own shampoo. Now, Margaux knows that the EU investments […]
Wiley Online Library, First published: 21 April 2019, https://doi.org/10.1111/cod.13294. Renato I. de Ávila Danillo F. M. C. Veloso Gabriel C. Teixeira Thaisângela L. Rodrigues Tim Lindberg Malin Lindstedt Simone G. Fonseca Eliana M. Lima Marize C. Valadares Abstract Background Allergic contact dermatitis reported to henna‐based hair coloring products (HPs) has been associated with adulteration of […]
To replace a test animal, which is clearly a complex system with blood and organs, you need a more holistic approach to model the entire allergic response within the body. Our CEO Anki Malmborg Hager explains the benefits of using alternative testing methods to prove product safety in this week’s Manufacturing Chemist. Read the article […]
Regulatory Toxicology and Pharmacology. Volume 103, April 2019, Pages 158-165 https://doi.org/10.1016/j.yrtph.2019.01.001 Matthew Stevenson, Lukasz Czekala, Liam Simms, Nicole Tschierske, Olivia Larne, Tanvir Walele Abstract Electronic cigarettes (e-cigarettes) are an increasingly popular alternative to combustible tobacco cigarettes among smokers worldwide. A growing body of research indicates that flavours play a critical role in attracting and retaining […]