Expert roundtable: How do we assess skin sensitization potency of Complex Mixtures?

Industry and scientific perspectives on current challenges, emerging approaches and new data on Essential Oils

How can reliable skin sensitization potency estimates be generated for Natural Complex Substances and other complex mixtures using New Approach Methodologies (NAMs)?

In this webinar, Joe Dawson, Product Safety Manager at dōTERRA, will present key findings from a recently published study comparing different approaches to quantitative potency assessment of Essential Oils.

The presentation will be followed by a live expert roundtable featuring speakers from dōTERRA, the Research Institute for Fragrance Materials (RIFM), and SenzaGen. Together, the panel will explore current challenges, practical applications, and future directions for skin sensitization potency assessment of complex mixtures.

For those who missed our EUROTOX session, this webinar also offers an opportunity to hear the scientific rationale and key findings behind the newly published study.

The webinar presentations will last around 25 minutes, followed by a 35-minutes live Q&A and expert roundtable discussion. If you cannot attend the live event, register now to get access to the recording 🎧.

What is your biggest challenge in skin sensitization potency assessment? Submit your question in the registration form and help shape the expert roundtable discussion. Selected questions and topics will be featured during the live session.

Key takeaways

• Insights from a newly published study comparing GARD^® skin Dose-Response, component-based prediction model, and historical LLNA data for Essential Oils.
• Current challenges and opportunities in quantitative skin sensitization potency assessment of Complex Mixtures.
• Expert perspectives on practical applications, challenges, and future directions in NAM-based potency assessment.

Speakers

Andy Forreryd, PhD
Scientific Liaison Manager @ SenzaGen

• Co-developer of the GARD^®skin assay (OECD TG 442E).
• Member of the ISO/TC 194/WG 8 on irritation and sensitization.
• Member of OECD expert group on respiratory sensitization.

Introduction to skin sensitization potency assessment and the single assay-based method GARD^® skin Dose-Response.

Joe Dawson
Product Safety Manager @ dōTERRA

• 12 years of experience as a research scientist in the food and cosmetics industries
• Expertise in product safety and scientific evaluation of consumer products
• B.Sc. in Molecular Biology, University of Utah, M.S. in Biomedical Informatics at the University of Utah School of Medicine (ongoing).

A comparative analysis of test methods for predicting dermal sensitization potency in Essential Oils.

Isabelle Lee, PhD
Manager of Human Health Science & Strategy @ RIFM

• Leads human health science and strategy, advancing NAMs for ingredient safety.
• Head of skin sensitization team, overseeing safety assessments and research programs.
• Expert in consumer product ingredient evaluation with a PhD in Pharmacology (UPenn).