Expert roundtable: How should we assess skin sensitization potency of complex mixtures?

Industry and scientific perspectives on current challenges, emerging approaches and new data on Essential Oils

How can reliable skin sensitization potency estimates be generated for Natural Complex Substances and other complex mixtures using New Approach Methodologies (NAMs)?

In this webinar, Joe Dawson, Product Safety Manager at dōTERRA, will present key findings from a recently published study comparing different approaches to quantitative potency assessment of Essential Oils.

The presentation will be followed by an expert roundtable discussion exploring current challenges, practical applications, and future directions for potency assessment of complex mixtures.

Join the discussion and hear different perspectives on an area of active scientific development in non-animal skin sensitization assessment.

For those who missed our EUROTOX session, this webinar also offers an opportunity to hear the scientific rationale and key findings behind the newly published study.

The webinar presentations will last around 25 minutes, followed by a 35 minutes of live Q&A and expert roundtable discussion. If you cannot attend the live event, register now to get access to the recording 🎧.

Key takeaways

• Insights from a newly published study comparing GARD^® skin Dose-Response, component-based prediction model, and historical LLNA data for Essential Oils.
• Current challenges and opportunities in quantitative skin sensitization potency assessment of Complex Mixtures.
• Expert perspectives on practical applications, challenges, and future directions in NAM-based potency assessment.

Expert roundtable discussion

Expert roundtable discussion featuring speakers from dōTERRA, SenzaGen and additional invited experts.

Confirmed speakers:

Andy Forreryd, PhD
Scientific Liaison Manager @ SenzaGen

• Co-developer of the GARD^®skin assay (OECD TG 442E).
• Member of the ISO/TC 194/WG 8 on irritation and sensitization.
• Member of OECD expert group on respiratory sensitization.

Introduction to skin sensitization potency assessment and the single assay-based method GARD^® skin Dose-Response.

Joe Dawson
Product Safety Manager @ dōTERRA

• 12 years of experience as a research scientist in the food and cosmetics industries
• Expertise in product safety and scientific evaluation of consumer products
• B.Sc. in Molecular Biology, University of Utah, M.S. in Biomedical Informatics at the University of Utah School of Medicine (ongoing).

A comparative analysis of test methods for predicting dermal sensitization potency in Essential Oils.