Gradin et al., Quantitative assessment of sensitizing potency using a dose-response adaptation of GARDskin. Nature Scientific Reports. September 23, 2021.
In vitro quantitative assessment of skin sensitizing potency
GARDskin Dose-Response is an in vitro test for quantitative skin sensitizing potency assessment of chemicals, adapted from GARDskin (OECD TG 442E).
GARDskin Dose-Response provides an estimated threshold concentration for a test substance to induce skin sensitizing effects; a lower concentration equals a higher potency and vice versa. This threshold concentration can be used for skin sensitizing potency ranking of candidate ingredients and early decision-making during product development.
Additionally, readouts provide a prediction of correlating LLNA EC3 values, which is traditionally used to measure the skin sensitizing potency of chemicals. Furthermore, the readout can also predict human skin sensitizing potency and/or GHS/CLP classification (1A or 1B), all with high statistical significance.
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Non-animal readout to predict:
- LLNA EC3 value
- Human skin sensitizing potency
- GHS/CLP classification (1A or 1B)
The number of biomarkers used in GARDskin Dose-Response.