GARD®skin Dose-Response.

In vitro skin sensitizing quantitative potency assessment

GARDskin Dose-Response is an in vitro test for quantitative skin sensitizing potency assessment of chemicals, adapted from GARDskin.

GARDskin Dose-Response provides an estimated threshold concentration for a test substance to induce skin sensitizing effects; a lower concentration equals a higher potency and vice versa. This threshold concentration can be used for skin sensitizing potency ranking of candidate ingredients and early decision-making during product development.

Additionally, the readout can be extrapolated to a correlating LLNA EC3 value, which is traditionally used to measure the skin sensitizing potency of chemicals. Furthermore, the readout can also be extrapolated to human skin sensitizing potency and/or GHS/CLP classification (1A or 1B), all with high statistical significance.

Are you looking for dose-response data?

GARDskin Dose-Response gives both qualitative and quantitative information related to skin sensitization. The non-animal test data can be used to predict:

  • LLNA EC3 value
  • Human skin sensitizing potency
  • GHS/CLP classification (1A or 1B)
200 genes

The number of biomarkers used in GARDskin Dose-Response.