GARD®skin Dose-Response.
In vitro quantitative assessment of skin sensitizing potency
GARDskin Dose-Response is an in vitro test for quantitative skin sensitizing potency assessment of chemicals, adapted from GARDskin (OECD TG 442E).
Safe dose level for your candidate ingredients
GARDskin Dose-Response provides an estimated threshold concentration for a test substance to induce skin sensitizing effects; a lower concentration equals a higher potency and vice versa. This threshold concentration can be used for skin sensitizing potency ranking of candidate ingredients and early decision-making during product development.
Point-of-Departure for risk assessment
The readouts can predict correlating LLNA EC3 values, which are traditionally used to measure the skin sensitizing potency of chemicals. Furthermore, it can predict human skin sensitizing potency (NESIL/NOEL) and/or GHS/CLP classification (1A or 1B), all with high statistical significance.
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Non-animal readout to predict:
- LLNA EC3 value
- Human skin sensitizing potency (NESIL/NOEL)
- GHS/CLP classification (1A or 1B)
Joint publication with L’Oréal
Toxics 2024. In Vitro Prediction of Skin-Sensitizing Potency Using the GARDskin Dose–Response Assay: A Simple Regression Approach
Joint publication with RIFM and IFF
Regulatory Toxicology and Pharmacology 2024. GARDskin dose-response assay and its application in conducting Quantitative Risk Assessment (QRA) for fragrance materials using a Next Generation Risk Assessment (NGRA) framework
Publication on assay performance
Nature Scientific Reports 2021. Quantitative assessment of sensitizing potency using a dose-response adaptation of GARDskin.
The number of biomarkers used in GARDskin Dose-Response.
