Join our upcoming webinar to explore the recent advancement in GARD® for Skin Sensitization assessment, with a specific focus on substances that fall outside the applicability domains of the conventional in vitro assays in the OECD Test Guidelines.
Our skin sensitization experts will address challenges posed by various Difficult-to-Test substances, discussing the applicability domain of key event-based NAMs and existing test strategies.
You will learn about the broad applicability of GARD®skin OECD TG442E as we present scientific data on Difficult-to-Test substances and exciting projects done in collaboration with industry partners:
Agrochemical Formulations | Formulated Lubricant Products | Indirectly Acting Haptens | Metals | Natural Extracts | Polymers | UVCBs
- NAMs and test strategies for skin sensitization testing of Difficult-to-Test samples.
- The applicability domain of GARD®skin for challenging substances and its integration into Defined Approaches.
- Case studies on Agrochemical Formulations, Formulated Lubricant Products, Indirectly Acting Haptens, Metals, Natural Extracts, Polymers, and UVCBs.
What are “difficult-to-test” substances?
In the context of skin sensitization testing, certain groups of chemicals are considered difficult to test using conventional cell-based methods. Examples of commonly recognised “difficult-to-test” samples include indirectly acting haptens, complex mixtures, and substances with low water solubility.