Maria Agemark new quality manager at SenzaGen

SenzaGen is in an expansive phase and is building up its team with new personnel. Maria Agemark has been recruited as quality manager and was previously working at the Department Immunotechnology at LTH . Maria has a PhD in biochemistry, where she conducted research on the Aquaporins in humans and plants.

– It is going to be exciting and challenging to work in a new company that is in an exciting early phase. I know the research behind the products well and look forward to be part of the new team that SenzaGen is setting up, says Maria Agemark .

Maria starts on SenzaGen in March 2015 and will focus on building up the new lab and quality systems.

– Maria has an expertise that we need to bring the company to the next level. I very much look forward to working together with Maria, says Anki Malmborg Hager, CEO of SenzaGen.

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SenzaGen receives financial support

SenzaGen is proud to be awarded financial support by IKS Accelerator.

Signature biomarker analysis for prediction of skin sensitizers using a cell-based in vitro alternative to animal experimentation

Henrik Johansson, Ann-Sofie Albrekt, Carl A.K. Borrebaeck, Malin Lindstedt
Department of Immunotechnology, Lund University, BMC D13, 21184 Lund, Sweden

Introduction
Allergic contact dermatitis is an inflammatory skin disease caused by immunological responses towards chemical haptens. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within pharmaceutical and cosmetic industries have stimulated significant research efforts to develop alternative, human cell-based assays for the prediction of sensitization.
We have developed a novel cell-based assay for the prediction of sensitizing chemicals, based on differentially regulated transcripts in the myeloid cell-line MUTZ-3.

 

Conclusions
We have identified a biomarker signature with accurate predictive power, which represents a compelling readout for an in vitro assay useful for the identification of human sensitizing chemicals. The biomarker signature include transcripts involved in relevant biological pathways, such as oxidative stress and xenobiotoic induced responses, which sheds light on the molecular interactions involved in the process of sensitization.

Poster:

Signature biomarker analysis for prediction of skin sensitizers using a cell-based in vitro alternative to animal experimentation_EAACI 2011 LTH_p