GARD®skin Dose-Response.

In vitro skin sensitizing quantitative potency assessment

GARDskin Dose-Response is an in vitro test for quantitative skin sensitizing potency assessment of chemicals, adapted from GARDskin.

GARDskin Dose-Response provides an estimated threshold concentration for a test substance to induce skin sensitizing effects; a lower concentration equals a higher potency and vice versa. This threshold concentration can be used for skin sensitizing potency ranking of candidate ingredients and early decision-making during product development.

Additionally, readouts can be extrapolated to correlating LLNA EC3 values traditionally used to measure skin sensitizing potency of chemicals. Furthermore, the readout can also be extrapolated to Basketter Human Potency classes and/or GHS/CLP classification, all with high statistical significance.

Are you looking for dose-response data?

GARDskin Dose-Response gives both qualitative and quantitative information related to skin sensitization. The non-animal test data can be extrapolated to:

  • LLNA EC3 value
  • Human potency category
  • GHS/CLP classification
200 genes

The number of biomarkers used in GARDskin Dose-Response.