Skin sensitization assay for safety assessment of chemicals
Allergic contact dermatitis is the most prevalent form of immunotoxic adverse effects induced by chemicals in consumer products and everyday surroundings. The symptomatic rash is caused by an immune response towards foreign substances in direct contact with the skin.
GARDskin enables a robust and accurate way of predicting the ability of chemicals to induce sensitization, without the use of animal experimentation in compliance with the 3R principle. It is a genomic test measuring changes in gene expression of 200 genes relevant to the skin sensitization adverse outcome pathways (AOP).
- GARDskin is included in OECD Test Guideline Program (TGP no. 4.106).