Allergic contact dermatitis is the most prevalent form of immunotoxic adverse effects induced by chemicals in consumer products and everyday surroundings. The symptomatic rash is caused by an immune response towards foreign substances in direct contact with the skin.
Complements to GARDskin for potency classification.
GARDpotency is an add-on to GARDskin, able to subcategorize sensitizers according to CLP/GHS classifications, by monitoring the expression of ~50 complementary genomic biomarkers.
The new guidelines for REACH registrations of chemicals include CLP categorization of skin sensitizers as Cat 1A for strong sensitizers, Cat 1B for moderate sensitizers and No Cat for non-sensitizers. This is the specific end-point of GARDpotency.
Animal free test for skin sensitization
Chemicals in consumer products
Screening of pharmaceutical candidates
GARD, Dendritic cells and high acccuracy. What’s the connection?
“All sensitization is dependent on activation of dendritic cells, the sentinels of the immune system. The GARD assay is based on these cells and delivers high accuracy. Since GARD is examining the expression from more than a hundred genes that are all collectively relevant for the AOP of skin sensitization, several key events are addressed in one single test.”
Says Henrik Johansson, Senior Scientist at SenzaGen
SenzaGen AB, Medicon Village
223 81 Lund, Sweden