Potency potential of chemicals using GARD shown by independent laboratory

The platform that forms the basis for the GARD sensitization assay, has been shown to have the potential to be an accurate tool for measuring the potency of sensitizing chemicals. The study was performed by an independent research group at Department of Immunotechnology, Lund University in Sweden and presented at the Society of Toxicology 55th Annual Meeting in New Orleans, 2016.

The new data were presented on Tuesday at the Society of Toxicology 55th Annual Meeting in New Orleans, poster session “Alternative Models for Ocular and Skin Toxicity”, abstract number 2205, P136.

-We have for a long time seen indications that this platform could predict potency and we are very happy to be able to present data that further points in that direction now, since it opens up completely new possibilities in skin sensitizations, says Assoc. Prof. Malin Lindstedt, heading the group at Department of Immunotechnology.

Based at Medicon Village in Lund, SenzaGen develops and implements animal-free tests on chemicals and proteins for classification of sensitizers, primarily for the cosmetics and pharmaceutical industries. SenzaGen’s test GARD
(Genomic Allergen Rapid Detection) measures significantly more parameters than existing tests on the market and has previously shown to deliver the most accurate prediction for hazard classification of chemicals. Now it has also shown potential to be a key player in the important field of risk assessment of chemicals by being able to predict the potency of chemicals.

-Potency has been the long-sought for application of sensitization tests. In risk assessment it is imperative to be able to predict not only the hazard of a chemical but more importantly how strong inducer of sensitization it is, i.e. the potency of the chemical. Lund University has now in a large study shown that GARD has this ability, which makes GARD unique, and we are looking forward to take part of this and develop it further, says Anki Malmborg Hager, CEO of SenzaGen AB.

Press release in pdf

SenzaGen establishes subsidiary in the US

To quickly strengthen its commercial presence in the US market, Swedish SenzaGen AB expands globally and establishes a subsidiary in California.

SenzaGen, which develops and implements non-animal allergy tests of chemicals and proteins, for the chemical, pharmaceutical and cosmetic industries, expands its sales organization and prepares the company for an IPO in 2017. Senzagen, a Lund University Department of Immunotechnology spin-out was recently recognized as one of Sweden’s most promising young and innovative companies.

– In line with our strategy to establish a commercial presence in key markets, Senzagen has established a subsidiary in the US. The US represents the world’s largest pharmaceutical and chemicals markets, and one of the largest within cosmetics. To capture market share, it is crucial that we have a local presence, says Anki Malmborg-Hager, CEO of SenzaGen AB.

Responsible for Senzagen’s US operations will be toxicologist Dr. Brian Rogers as US CEO, and Head of business development will be immunologist Dr. Sandra Reynoso.

-Nearly 50% of all animal research experiments today are performed in the US, and we want to be there to help replace these tests and offer the market a better and much safer test with our GARD. Together with our local team and their strong network, I look forward to building SenzaGen’s brand as the market leader in allergy testing in the US, says Anki Malmborg-Hager.

For more information, please contact:
Anki Malmborg Hager, PhD, CEO
E-mail: amh@senzagen.com
SE: +46 768 284822

Press release in pdf

SenzaGen is presenting at a hosted session at Society of Toxicology 55th Annual Meeting in New Orleans March 15, 2016

SenzaGen Senior Scientist, Dr. Henrik Johansson will give a presentation at an
exhibitor hosted
session at the Society of Toxicology 55th Annual Meeting in New Orleans, 15th of March.

The meeting promises more than 150 scientific sessions, approximately 350 ToxExpo exhibitors offering you the latest information on services and technology, thousands of abstract presentations, continuing education courses, awards presentations, receptions, career guidance and support, and more.

The topic for Dr. Johansson’s presentation,
Genomics—The Future of Sensitization Testing and Safety Assessment
is
:

In vitro testing in human cellines using genomic technology is the future in safety testing of chemicals and proteins. SenzaGen is presenting their use of genomics for sensitization testing with GARD assays for skin and respiratory sensitization. Using +200 biomarkers enables better predictions, including potency information.

This session is an Exhibitor-Hosted Session. Although not an official part of the SOT Annual Meeting scientific program, its presentation is permitted by the Society.

The presentation will cover

  • Accurate and convenient safety assessment of chemical sensitizers using GARD, an in vitro assay based on genomic biomarker signatures
  • How genomic readouts can help facilitate simple models that effectively monitors a complex reality
  • Versatile test systems allowing for a broad applicability domain

Attendees are welcomed from researcher community, industry, manufacturers, regulatory agencies, consultants, CROs and every one interested in safety testing of chemical compounds.

Details:

Genomics—The Future of Sensitization Testing and Safety Assessment

Exhibition hall, Room 211

Tuesday, March 15, 1:30 PM to 2:30 PM

Tags:

SenzaGen signs new customer – entry into the pharmaceutical industry

In line with its strategy, SenzaGen has signed a strategic contract with a major international pharmaceutical company. The agreement opens up a whole new market for GARD, which previously has been used primarily for testing in the cosmetics industry. This means that SenzaGen’s test GARD will be used for the testing of drug candidates in early development.

Based at Medicon Village in Lund, SenzaGen develops and implements animal-free allergy tests for chemicals and proteins.SenzaGen’s test, GARD (Genomic Allergen Rapid Detection), has been developed over 15 years and measures significantly more parameters than existing tests on the market. This makes GARD a safer and more effective test than other available options. So far, GARD has primarily been used for testing in the cosmetics industry to detect potential allergens in products, but it is now entering the pharmaceutical industry.

-Since the start, collaborations with pharmaceutical companies have been a major objective for SenzaGen. We see great potential in this market and we are looking forward to learning more about the industry, with ambition to develop and offer GARD to even more customers in the pharmaceutical industry, says Anki Malmborg Hager, CEO SenzaGen

This is the first time that a pharmaceutical customer uses SenzaGen’s method. The main advantage of using GARD is that the test is based on genomic technology and is performed in vitro.

The tests can be performed in a very early phase of drug development, which helps pharmaceutical companies to develop safer drugs at a faster pace and at a lower cost.

For more information:
Anki Malmborg Hager, CEO, SenzaGen AB
E-mail: amh@senzagen.com
Phone: +46 768 284822

Press release in pdf

SenzaGen reinforces its sales organization – recruiting Peter Sandberg

SenzaGen has recruited Peter Sandberg as Director of Sales. Peter has long experience from a number of positions and companies active in the life science sector in the last thirty years. By recruiting Peter Sandberg SenzaGen strengthens its sales organization and the commercial development of the company.

With the base at Medicon Village in Lund SenzaGen develops and implements animal free allergy tests of chemicals and proteins, especially for the cosmetic and pharmaceutical industry. SenzaGen’s test GARD (Genomic Allergen Rapid Detection) has been developed over 15 years and measure significantly more parameters than existing tests on the market. It makes GARD a safer and more effective test than other options. GARD eliminates the need for animal testing and enables customers to develop and provide safer consumer products as well as offer their employees a better working environment.

“SenzaGen is in an expansive phase at the moment, and we see an increased interest in allergy tested and safe products in the cosmetic and pharmaceutical market. The recruitment of Peter Sandberg will allow us to meet market interest and substantially increase our sales activities”, says Anki Malmborg Hager, CEO of SenzaGen.

Peter Sandberg has a B.Sc. in Genetics and has worked primarily with sales, product launches and branding, for over thirty years. With experience from BioInvent, self-employment in the GTF AB and Celltox AB Peter Sandberg helped to build and develop a variety of companies and has a wide network of contacts throughout the industry. Peter Sandberg comes from Fisher Scientific’s Nordic operations, where he was General Manager for many years where he built up sales operations.

“SenzaGen is an exciting company and GARD is a product with great potential. So when I got the chance to contribute, it felt as exciting challenge. I believe that my experience in combination with SenzaGen’s innovation can generate new opportunities for the future”, says Peter Sandberg, new Director of Sales at SenzaGen AB.

For more information:
Anki Malmborg Hager, CEO, SenzaGen AB
E-mail: amh@senzagen.com
Phone: +46 768 284822

Peter Sandberg, Director of sales SenzaGen AB
E-mail: peter.sandberg@senzagen.com
Phone: +46 708 204481

Press release in pdf

SenzaGen´s share issue oversubscribed – raises MSEK 44

SenzaGen has just completed a share issue to accelerate the company’s rapidly growing revenues, scale up the sales organization, complete ongoing validation processes and develop new tests in the GARD portfolio. The interest has been overwhelming which is why the Company, at an Extraordinary General Meeting on Monday, October 5, 2015 decided to extend the offer from MSEK 25 to 44. Vator Securities acted financial advisor regarding the share issue.

-The interest regarding our share issue has exceeded all expectations. It is an acknowledgment of the superiority of SenzaGens test, and the need for animal free allergy tests in the market, says Anki Malmborg Hager, CEO at SenzaGen.

With their base at Medicon Village in Lund, SenzaGen develops and implements animal free allergy tests of chemicals and proteins, especially for the cosmetic and pharmaceutical industry. SenzaGen’s test GARD (Genomic Allergen Rapid Detection) is based on more than 15 years of research and measures significantly more parameters than existing tests on the market. It makes GARD a much safer and more effective test than other options. GARD eliminates the need for animal testing and enables customers to develop and provide safer consumer products and to offer their employees a better working environment.

SenzaGen’s original ambition was to bring in MSEK 25. As a result of the great interest in the Company, it was decided at an Extraordinary General Meeting on Monday, October 5, 2015 to increase the share issue to MSEK 44, even if the interest was much higher. The proceeds will primarily finance the scaling up of the sales organization, validation process and the development of new tests in the GARD portfolio. In addition to the financing and development of the operational business, SenzaGen will also aim at listing the company on First North during 2017.

-As the interest for our GARD products is growing, we are also aiming at listing the company on First North in order to facilitate and finance the continued expansion and development internationally, says Anki Malmborg Hager.

Vator Securities acted financial advisor.

For more information, please contact:
Anki Malmborg Hager, CEO, SenzaGen AB
Mail: amh@senzagen.com
Phone: +46 768 284822

Chemical and cosmetics industries
Under new EU legislation, a total ban of animal testing in cosmetics development has been issued. Even before the ban, it was mandatory for chemical producers to make use of alternative test methods instead of animal testing if satisfactory methods were available. The regulatory pressure gives SenzaGen very good conditions for a rapid market penetration.

Pharmaceutical industry
Out of the about 10.000 molecules that are produced in drug-development today, usually only one is finally approved. This results in significant costs that do not lead to revenue. One of the reasons is that drug projects often fail because the drug has subsequently proved to be toxic in humans. At that stage, a lot of capital has already been invested in several years of lab and animal studies. Therefore, the pharmaceutical industry is looking for in vitro tests earlier in the process, which can show whether a molecule affects the human immune system negatively.

Within SenzaGen’s two main areas (skin sensitization and respiratory allergies), the company estimates that over 200 000 tests are conducted annually in the pharmaceutical industry with a market value of SEK 9.2 billion. The percentage of in vitro tests in the pharmaceutical industry in for example Great Britain has since 2000 increased from 2.4 percent to 21.5 percent in 2013.

Press release in pdf

diplom

Anki Malmborg Hager, CEO of SenzaGen through to final in SKAPA innovation prize

Anki Malmborg and SenzaGen is one of the two winners of the region final of Sweden’s biggest innovation prize, the SKAPA Prize. The winner of this development prize and the winners of the prize for Future Innovators were presented last Monday in a ceremony at the High Court in Malmö. The governor Margaret Pålsson and ALMI Skåne’s CEO Anders Norman handed out the prizes to the proud winners. All four winners are moving on to the national finals.

In the motivation for giving the prize for SKAPA-innovation to Anki Malmborg you can read:
The company has presented advanced research in a transparent, commercial manner and has quickly proven that it can significantly minimize the proportion painful animal testing considerably, as well as it wil deliver added value to their different customer groups.

Read the press release on ALMI’s newsdesk (in Swedish)

diplom

SenzaGen wins innovation prize SKAPA and is appointed as provincial finalist

SenzaGen has won yet another award and was recently appointed the provincial finalist in Skåne and will thereby have the opportunity to win the national innovation award SKAPA, the country’s largest and most prestigious innovation prize. The SKAPA Prize is awarded to innovators in order to support the commercialization of their products.

The prize is awarded by the Foundation SKAPA in cooperation with ALMI. It is the regional ALMI companies in cooperation with local inventors’ associations affiliated to the Swedish Inventors Association which has chosen the county finalists for the award.

The appointment means that SenzaGen have the opportunity to be appointed Swedish champion of innovation. As the county finalist, SenzaGen receives a prize worth SEK 25 000 with the option to gain an additional SEK 550 000 (maximum spread over three laureates) if they succeed as winners of the national prize.

– SenzaGen has been able to package advanced research in a transparent, commercial way and have in a short time shown that they will be able to both significantly minimize the number of animal tests  being performed and deliver a better accuracy in the tests and hence a better value to their customers. It is going to be very exciting to follow the company in the future! says Johan Olsen, ALMI

The national final is being held on 5 Nov 2015 in Stockholm.

senzagen member of the board

Ian Kimber joins the board of SenzaGen AB

SenzaGen AB, a diagnostic spin-off company from Lund University, is proud to announce that Prof. Ian Kimber will join the Board of Directors.

SenzaGen AB is a diagnostic company working to replace animal testing for sensitization predictions.

Prof Ian Kimber is currently Professor of Toxicology and Associate Dean for Business Development in the Faculty of Life Sciences at the University of Manchester. He has broad research interests at the interface between toxicology and immunology, with a particular focus on allergy and inflammation.  Professor Kimber holds, and has held, a variety of positions on national and international expert and scientific advisory committees. Currently these include the following:  Member UK Medicines and Healthcare products Regulatory Agency (MHRA) Committee for Safety of Devices, Programme Advisor Food Standards Agency Food Allergy and Intolerance Research Programme, and member MRC Translational Research Group. Professor Kimber was previously President of the British Toxicology Society (BTS) (2012-2014), and Chairman of the Board of the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) (2008-2013).  

“I am delighted to be joining the Board of SenzaGen at such an exciting period of growth. Since our initial studies that led to the development and ultimate validation of the Local Lymph Node Assay I have maintained a keen interest in chemical allergy and in the development of novel approaches for improved hazard identification and risk assessment. In this respect harnessing fully the opportunities afforded by developments in the biomedical sciences is critical, and the work of SenzaGen in exploiting a genomic approach to pathway analysis and risk assessment is at the cutting edge of new developments”, says Prof Kimber.

Ian Kimber has published over 600 research papers, review articles and book chapters, and serves currently on the editorial boards of toxicology, immunology, dermatology and pathology journals.

“We are very happy to have Prof Kimber on board in SenzaGen”, since he is one of the forerunners in sensitization testing, says Prof Carl Borrebaeck, “his knowledge and interest in the field of allergy and replacement of animal testing with new technologies is very important to us. We value his participation in developing the next generation tests.”

 

Press release in pdf

SenzaGen one of the five most praised companies in Swedish business media

SenzaGen one of the five most praised companies at Ny Teknik & Affärsvärldens big Inovation Event for the 33 most promising young innovativ companies in Sweden.

The final ceremony for the 33-list was held in Stockholm were the hottest new technology companies in Sweden were presented. The list is presented without ranking but five companies were elected for special attention and SenzaGen was awarded a prize from ALMI, a strategic partner and SenzaGen given investment money for further development of the company.

Anki Malmborg Hager, CEO of SenzaGen features in film about the company from the event.
Film  (in Swedish)

About the 33-list
The 33-list is based on nominations by companies from all over Sweden and the winners are appointed jointly by the editorial staff of the NyTeknik and Affärsvärlden. The jury looks for companies with a unique product or service based around a clear innovation with great international potential – an innovation that has the potential to change the rules of the game in their industry. To make it on the list must now be based in Sweden up to 7 years old. For more information, visit http://www.33-listan.se