SenzaGen CEO Anki Malmborg Hager presents at Swetox conference on future research without animal testing

SenzaGen’s CEO, Anki Malmborg Hager, gives a presentation today on October 17, entitled: A new, animal-free allergy test with the goal of becoming a “golden standard” for risk assessment in the cosmetics and chemical industry. An innovation company with the next generation tests tells their story. The presentation will take place during the SWETOX conference […]

SenzaGen’s CEO, Anki Malmborg Hager, gives a presentation today on October 17, entitled: A new, animal-free allergy test with the goal of becoming a “golden standard” for risk assessment in the cosmetics and chemical industry. An innovation company with the next generation tests tells their story. The presentation will take place during the SWETOX conference at Hasselbacken in Stockholm

The conference, The Future on Research on Animal-Free Methods, is organized by SWETOX and is part of the communication “New Animal-Free Methods to Meet the Need for Safe Chemicals” funded by the Research Council FORMAS. SWETOX visions on reaching A Safe Chemical World and Toxicological Risk Assessment Without Animal Experiments, will be the starting point of the day.

The conference aim is to bring innovative people together and it is led by speakers from several pioneering research areas in animal-free research. The conference also addresses the political arena with closing discussions with Swedish politicians on site.

SWETOX is a national research centre for toxicology, a collaboration between eleven Swedish universities. The hub of the cooperation is a state-of-the-art and well-equipped facility in Gärtuna, outside Södertälje.

For more information about the conference (Swedish)
http://swetox.se/event/swetox-replacement-workshop/

For more information
Anki Malmborg Hager, vd, SenzaGen AB
Email: anki.malmborg.hager@senzagen.com
Telephone: +46 768 284822

Malin Lindstedt, founder of SenzaGen and GARD, is awarded the NYTÄNKAREN 2017 (INNOVATIVE THINKER 2017) prize by the Swedish foundation Research Without Animal Experiments

SenzaGen’s co-founder, Professor Malin Lindstedt, has been awarded the Nytänkaren 2017 (Innovative Thinker 2017) Prize and SEK 400,000 by the Swedish fundation for Research Without Animal Experiments for her work on the development of animal-free testing methods. The prize was awarded today, 16 October at a ceremony at Research Without Animal Experiments offices in Stockholm. […]

SenzaGen’s co-founder, Professor Malin Lindstedt, has been awarded the Nytänkaren 2017 (Innovative Thinker 2017) Prize and SEK 400,000 by the Swedish fundation for Research Without Animal Experiments for her work on the development of animal-free testing methods. The prize was awarded today, 16 October at a ceremony at Research Without Animal Experiments offices in Stockholm.

Professor Malin Lindstedt receives the prize for her successful development of advanced testing methods that can reduce and replace the use of animals in the risk assessment of chemicals and consumer products. Malin Lindstedt works at Lund University’s Department of Immunotechnology, where she has directed the research that lies behind the series of allergy tests based on cell-based gene analysis that are now marketed under the name GARD. Under her direction, a research team started by developing a test for skin allergies. They then went on to develop a test to determine which substances can cause respiratory allergies, and most recently a test that can analyze proteins associated with food allergies.

While working on the development of the technology behind GARD, Malin Lindstedt founded SenzaGen, the company which is now responsible for making this technology available on the global market. The first test to be developed, GARDskin, is already seeing limited use. GARDskin is at the present time undergoing a validation process for inclusion in the OECD Chemical Test Guidelines, which would result in the method achieving its international breakthrough as an eligible method that meets regulatory requirements for the risk assessment of chemicals.

The prize from Research Without Animal Experiments highlights the practicability of using advanced methods to continue to reduce and replace the use of animals in the risk assessment of chemicals and consumer products both inside and outside Sweden. With the NYTÄNKAREN prize and its associated funding, Research Without Animal Experiments wishes particularly to support the research team’s ambitions to continue their development of allergy tests.

 

News about the prize can be viewed on the Research Without Animal  Experiments website:

http://forskautandjurforsok.se/knappar-pa-startsidan/nytankaren-2017/

 

For more information

Anki Malmborg Hager, CEO, SenzaGen AB
Email: anki.malmborg.hager@senzagen.com
Telephone: +46 768 284822

Grundaren av SenzaGen och GARD, Malin Lindstedt, tilldelas priset som NYTÄNKAREN 2017 av stiftelsen Forska Utan Djurförsök

SenzaGens medgrundare, Professor Malin Lindstedt har tilldelats utmärkelsen Nytänkaren 2017 och 400 000 kronor av stiftelsen Forska Utan Djurförsök för sitt arbete med utveckling av djurfria testmetoder. Idag delades priset ut vid en sammankomst hos stiftelsen Forska Utan Djurförsök Stockholm Professor Malin Lindstedt får priset för sin framgångsrika utveckling av avancerade testmetoder som kan minska […]

SenzaGens medgrundare, Professor Malin Lindstedt har tilldelats utmärkelsen Nytänkaren 2017 och 400 000 kronor av stiftelsen Forska Utan Djurförsök för sitt arbete med utveckling av djurfria testmetoder. Idag delades priset ut vid en sammankomst hos stiftelsen Forska Utan Djurförsök Stockholm

Professor Malin Lindstedt får priset för sin framgångsrika utveckling av avancerade testmetoder som kan minska och ersätta användningen av djur vid riskbedömning av kemikalier och konsumentprodukter.  Malin Lindstedt arbetar på Institutionen för Immunteknologi, Lunds universitet, där hon lett forskningen som ligger bakom den serie allergitester som nu marknadsförs under namnet GARD och som utgår från cellbaserade genanalyser. Under hennes ledning började en forskargrupp med att utveckla ett test för hudallergier. De har sedan fortsatt utvecklingen med ett test för att avgöra vilka ämnen som kan orsaka luftvägsallergier, och nu senast ett test som kan analysera proteiner som är förknippade med matallergier.

Under sitt arbete med att utveckla teknologin bakom GARD grundade Malin Lindstedt företaget SenzaGen, som nu ansvarar för att göra teknologin tillgänglig på den globala marknaden. Det först utvecklade testet, GARDskin, har redan börjat användas i begränsad omfattning. GARDskin ingår i en valideringsprocess för att upptas i OECD:s testriktlinjer för kemikalier, vilket skulle leda till att metoden får internationellt genomslag som valbar metod för att uppfylla regulatoriska krav för riskbedömning av kemikalier.

Priset från Forska utan Djurförsök belyser möjligheten att med avancerade metoder fortsätta att minska och ersätta användning av djur vid riskbedömning av kemikalier och konsumentprodukter i och utanför Sverige. Forska Utan Djurförsök vill med NYTÄNKAREN och tillhörande anslag särskilt stödja forskargruppens ambitioner att fortsätta utvecklingen av allergitester.

Nyheten om priset hos Stiftelsen Forska Utand Djurförsök
http://forskautandjurforsok.se/knappar-pa-startsidan/nytankaren-2017/

 

För mer information:
Anki Malmborg Hager, vd, SenzaGen AB
Email: anki.malmborg.hager@senzagen.com
Telefon: 0768 284822

 

 

New colleague at SenzaGen

Welcome to SenzaGen Henrik Appelgren! Henrik has started his position as Chief Scientific Officer with us here at SenzaGen this week. Henrik is a biologist with a PhD in genetic toxicology. He has been working at the Swedish Chemicals Agency for 15 years, where he worked as Sweden’s national coordinator in the OECD Test Guideline […]

Welcome to SenzaGen Henrik Appelgren!

Henrik has started his position as Chief Scientific Officer with us here at SenzaGen this week. Henrik is a biologist with a PhD in genetic toxicology. He has been working at the Swedish Chemicals Agency for 15 years, where he worked as Sweden’s national coordinator in the OECD Test Guideline Programme. Henrik has a deep knowledge in alternative test methods and of regulatory work in the chemical industry – both nationally and internationally. He also has long experience of health risk assessments of chemicals in all European legislation. He is, and has been, a member of several scientific expert councils including FORMAS, the Swedish Research Council, the Swedish Fund for Research Without Animal Experiments, the Scandinavian Society for Cell Toxicology and EUToxRisk.

Henrik strengthens SenzaGen’s management for the commercialization of the GARD tests and prior to the company’s planned listing on Nasdaq First North.

We are very happy to have you in our team, Henrik!

SenzaGen is presenting at hosted session at the EUROTOX Congress in Bratislava

SenzaGen new Chief Scientific officer Hernik Appelgren will give a presentation on 21st century testing for skin sensitisation and updates on application of the GARD platform at The 53rd  European Congress of the European Societies of Toxicology, EUROTOX, on the 12th of Sept. SenzaGen is also Exhibiting at the congress and presenting two posters The […]

SenzaGen new Chief Scientific officer Hernik Appelgren will give a presentation on 21st century testing for skin sensitisation and updates on application of the GARD platform at The 53rd  European Congress of the European Societies of Toxicology, EUROTOX, on the 12th of Sept. SenzaGen is also Exhibiting at the congress and presenting two posters

The meeting promises scientific sessions houndreds of abstract presentations, exhibitors meetings, continuing education courses, awards presentations, receptions,  and  an exhibition area for exhibitors offering you the latest information on services and technology
Presentation details
Tuesday 12 Sep 10-11 AM | 
Memories, Hotel Sheraton
21st Century Sensitisation testing: Can one test be stand alone? Regulatory challenges and GARD applications update
.

Presented by: Henrik Appelgren, Chief Scientific Officer and regulatory expert at SenzaGen

Allergy is a growing health problem in humans. The data requirements for the assessment of sensitisation in chemical legislations have been based on animal assays, which until now have served as the golden standard. However, in vitro assays have been developed which need to be combined in order to address all key events for sensitisation to fulfil the demands in e. g., Reach. However, The Genomic Allergen Rapid Detection Skin (GARDskin) assay addresses all the key regulatory questions regarding sensitisation, including potency – How? This session we will give an update on the validation status and the different applications of GARD.

Posters
ID 668 | Session 2 | Board no P-04-02-07 | Monday, Sept 11 from 15:00
Transferability of the GARDskin assay to two independent laboratories.

ID 438 | Session 4 | Board number P-09-02-31 | Tuesday, Sept 12 from 15:00
The GARD platform for potency assessment of skin sensitizing chemicals

Vatorpodden – intervju med VD och styrelseordförande

Integrated hazard identification of chemical sensitizers using in vitro and in silico readouts – A comparative evaluation of predictive performance

By Lhasa Donna Macmillan, Henrik Johansson, Olivia Larne, Malin Lindstedt 1. Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS 2. SenzaGen, Lund, Sweden 3. Lund University, Lund, Sweden   Introduction There has been a significant drive to reduce, refine and replace animal models for the prediction of skin sensitization. This is in part due […]

By Lhasa

Donna Macmillan, Henrik Johansson, Olivia Larne, Malin Lindstedt
1. Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS
2. SenzaGen, Lund, Sweden
3. Lund University, Lund, Sweden

 

Introduction

There has been a significant drive to reduce, refine and replace animal models for the prediction of skin sensitization. This is in part due to the implementation of EU regulation 1223/20091 which prohibits the sale and marketing of any cosmetics and cosmetic ingredients which have been tested on animals, alongside REACH2 and CLP3 regulations which state that non-animal methods must be exhausted prior to considering the use of animal tests. The use and availability of non-animal methods is ever-increasing and 3 assays have been validated by the OECD thus far; the in chemico DPRA, the in vitro KeratinoSens™ and the in vitro h-CLAT. A number of other assays are undergoing OECD validation, including the GARDskin assay (Genomic Allergen Rapid Detection), a dendritic cell-based assay which identifies skin sensitizers from 200 genomic biomarkers4. However, it is generally accepted that no single non-animal method can be used as a standalone approach to replace animal models such as the murine local lymph node assay (LLNA). The focus has instead turned to combining multiple in chemico/in vitro/in silico assays and/or molecular descriptors to derive a more accurate assessment of hazard or risk, known as integrated testing strategies (ITS)5. The GARDskin assay has demonstrated high predictivity and has been reported as ready to use in an ITS6, therefore, it was decided to investigate the effect on performance when GARD was used in combination with Derek Nexus – and to compare these results against Derek with the DPRA, KeratinoSens™ and h-CLAT.

 

Conclusion

Using Derek skin sensitization predictions in combination with in chemico/in vitro assay results has a beneficial effect when predicting the LLNA outcome. GARDskin in particular performs extremely well when used with Derek in a conservative call approach. Human sensitization is more challenging to predict and GARDskin performs less well for this compared to predicting the LLNA – attributed to the small number of chemicals with both GARDskin and human data (n = 57), in addition to the positive bias in the GARD dataset (70%). However, the addition of Derek predictions clearly improve assay performance. Future work will focus on repeating this analysis on a larger, more balanced dataset.

Poster at Lhasa website
https://www.lhasalimited.org/publications/integrated-hazard-identification-of-chemical-sensitizers-using-in-vitro-and-in-silico-readouts-a-comparative-evaluation-of-predictive-performance/4428

 

New colleague at SenzaGen

Welcome to SenzaGen Anna Chérouvrier Hansson! Anna has started her position as Chief Commercial Officer with us here at SenzaGen this week. Anna comes from Camurus, a pharmaceutical company developing and commercializing innovative and long-acting medicines for the treatment of severe and chronic conditions. At Camurus, Anna was Director of Marketing and responsible for the […]

Welcome to SenzaGen Anna Chérouvrier Hansson!

Anna has started her position as Chief Commercial Officer with us here at SenzaGen this week. Anna comes from Camurus, a pharmaceutical company developing and commercializing innovative and long-acting medicines for the treatment of severe and chronic conditions. At Camurus, Anna was Director of Marketing and responsible for the Medical Device Business Unit. She has previously worked as Head of Business Development Life Science at Invest in Skåne, Partner at Zitha Consulting and in a number of senior positions in European pharmaceutical and chemical companies. Anna was born in France, studied and worked in Germany and Luxembourg before moving to Sweden in 2000 to study a Master in Business Administration and Business Law and decided to stay. Anna strengthens SenzaGen’s management for the commercialization of the GARD tests and prior to the company’s planned listing on Nasdaq First North.

We are very happy to have you in our team, Anna!

senzagen skin derma

Möt oss i Almedalen – Forskarna bakom GARDtestet och SenzaGens tekniker på plats.

Möt Andy Forreryd från Lunds Universitet och Angelica Johansson från SenzaGen i Forska Utan Djurförsöks event 6 och 7 Juli. Under två seminarier berättar Andy om forskningen bakom GARD. Det bjuds möjligheter till frågor och att testa på praktiskt labbarbete med testet. Med forskningspengar från bland andra Forska Utan Djurförsök har universitetet utvecklat ett unikt […]

Möt Andy Forreryd från Lunds Universitet och Angelica Johansson från SenzaGen i Forska Utan Djurförsöks event 6 och 7 Juli. Under två seminarier berättar Andy om forskningen bakom GARD. Det bjuds möjligheter till frågor och att testa på praktiskt labbarbete med testet.
Med forskningspengar från bland andra Forska Utan Djurförsök har universitetet utvecklat ett unikt allergitestet som med högre precision än befintliga tester kan avgöra om en kemikalie kan framkalla hudallergi. Testet utförs i provrör och ersätter befintliga djurtester vid säkerhetstestning av kemikalier. GARDtestet ägs, säljs och marknadsförs nu av SenzaGen AB för global kommersialisering med målet att bli ny branschstandard på den internationella marknaden för säkerhetstestning av kemikalier. Angelica Johansson finns på plats att berätta om GARDs resa från labb till global marknad. Tryck här för att läsa mer.

senzagen skin derma

Meet us in Almedalen – The researchers behind the GARDtest and SenzaGen’s lab technicians on site.

Meet Andy Forreryd from Lund University and Angelica Johansson from SenzaGen in the organisation of Research Without Animal Experiments, 6th and 7th of July. During two seminars, Andy will tell us about the research behind GARD. There will be opportunities for questions and hands on practical lab work so that you can experience and see […]

Meet Andy Forreryd from Lund University and Angelica Johansson from SenzaGen in the organisation of Research Without Animal Experiments, 6th and 7th of July. During two seminars, Andy will tell us about the research behind GARD. There will be opportunities for questions and hands on practical lab work so that you can experience and see how the test works.

With research money from different organisations, including Research Without Animal Experiments, the university has developed a unique allergy test that with higher precision than existing tests can determine if a chemical can induce skin allergy. The test is carried out in test tubes and replaces the need for animal testing when safety testing chemicals.

The GARDtestet is now owned, sold and marketed by SenzaGen AB for global commercialization with the aim of becoming a new industry standard on the international chemical safety testing market. Angelica Johansson is on site to talk about GARD’s journey from laboratory to global market. Link in Swedish.