Entries by Hanna Frykman

Pattern rules: biomarker signatures for sensitization as an alternative to animal testing

Biomarkers in Medicine, December 2011 ,Vol. 5, No. 6 , Pages 809-811 (doi: 10.2217/bmm.11.82) Lindstedt M., Borrebaeck C.A.K. “Identification of relevant endpoints and biomarkers is essensial for development of alternative assays predicting sensitisation. Omics-based techniques have recently generated very promising biomarker patterns, as well as pathways, which will be used in the identification of sensitising agents” […]

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests.

BMC Genomics. 2011 Aug 8;12:399. doi: 10.1186/1471-2164-12-399. Johansson H., Albrekt A.S., Lindstedt M., Borrebaeck C.A.K Abstract BACKGROUND: Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current […]

Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells

Immunology. 2006 Feb; 117(2): 156–166. doi:  10.1111/j.1365-2567.2005.02274.x Larsson K., Lindstedt M., Borrebaeck C.A.K. ABSTRACT The incidence of allergy is steadily increasing, but the molecular mechanisms involved in the allergic immune response are still not fully understood. In particular, further investigations focusing on dendritic cells, which are central in orchestrating the immune response, are needed. The […]