Entries by Hanna Frykman

SenzaGen recruits Dr. Anki Malmborg Hager as CEO

We are very happy to have been able to recruit Dr. Malmborg, who has extensive experience from commercialization of academic results, financial markets and business developments says Prof.Carl Borrebaeck, chairman of the Board of SenzaGen. Anki Malmborg Hager has more than 20 years´ experience in both pharmaceutical and biotech companies that are spin-offs from the […]

Genomic allergen rapid detection in-house validation-a proof of concept.

Toxicol Sci. 2014 Jun;139(2):362-70. doi: 10.1093/toxsci/kfu046. Epub 2014 Mar 27. Johansson H., Rydnert F., Kuehnl J., Schepky A., Borrebaeck C.A.K., Lindstedt M. Abstract Chemical sensitization is an adverse immunologic response to chemical substances, inducing hypersensitivity in exposed individuals. Identifying chemical sensitizers is of great importance for chemical, pharmaceutical, and cosmetic industries, in order to prevent […]

Human blood dendritic cell subsets exhibit discriminative pattern recognition receptor profiles

Immunology. 2014 Jun;142(2):279-88. doi: 10.1111/imm.12252. Lundberg K., Rydnert F, Greiff L, Lindstedt M. Abstract Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), enables antigen recognition and mediates appropriate immune responses. Distinct subsets of human […]

Evaluation of high throughput gene expression platforms using a genomic biomarker signature for prediction of skin sensitization.

BMC Genomics. 2014 May 16;15:379. doi: 10.1186/1471-2164-15-379. Forreryd A., Johansson H., Albrekt A.S., Lindstedt M Abstract BACKGROUND: Allergic contact dermatitis (ACD) develops upon exposure to certain chemical compounds termed skin sensitizers. To reduce the occurrence of skin sensitizers, chemicals are regularly screened for their capacity to induce sensitization. The recently developed Genomic Allergen Rapid Detection […]

Prediction of skin sensitizers using alternative methods to animal experimentation.

Basic Clin Pharmacol Toxicol. 2014 Jul;115(1):110-7. doi: 10.1111/bcpt.12199. Epub 2014 Feb 18. Johansson H., Lindstedt M. Abstract Regulatory frameworks within the European Union demand that chemical substances are investigated for their ability to induce sensitization, an adverse health effect caused by the human immune system in response to chemical exposure. A recent ban on the […]

Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency.

BMC Pharmacol Toxicol. 2014 Feb 11;15:5. doi: 10.1186/2050-6511-15-5. Albrekt A.S., Johansson H., Borrebaeck C.A.K., Lindstedt M. Abstract BACKGROUND: Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly prioritized. To date, proposed in vitro […]

GARD – Genomic Allergen Rapid Detection. A Testing Strategy for Assessment of Chemical Sensitizers

Doctoral thesis defense date 2013-06-05 09:00     ISBN978-91-7473-519-2 Johansson, Henrik LU Abstract (Swedish) Popular Abstract in Swedish Vi lever i en tid och i ett samhälle där kemikalier har blivit en naturlig del av vår industrialiserade vardag. Till stor del ligger kemikalieindustrin bakom flera av de stora tekniska framsteg som gör att västvärlden har […]

The GARD assay for assessment of chemical skin sensitizers.

Toxicol In Vitro. 2013 Apr;27(3):1163-9. doi: 10.1016/j.tiv.2012.05.019. Epub 2012 Sep 29. Johansson H., Albrekt A.S., Borrebaeck C.A.K., Lindstedt M Abstract Allergic contact dermatitis is a skin disease caused by an immunologic reaction to low molecular weight compounds, so called haptens. These substances are commonly present in products used by humans in daily life, such as […]

Pattern rules: biomarker signatures for sensitization as an alternative to animal testing

Biomarkers in Medicine, December 2011 ,Vol. 5, No. 6 , Pages 809-811 (doi: 10.2217/bmm.11.82) Lindstedt M., Borrebaeck C.A.K. “Identification of relevant endpoints and biomarkers is essensial for development of alternative assays predicting sensitisation. Omics-based techniques have recently generated very promising biomarker patterns, as well as pathways, which will be used in the identification of sensitising agents” […]